Indication
This combination may be used in-
Chronic pains like sciatica
Lumbago
Trigeminal neuralgia
Facial paralysis
Optic neuritis
As well as neuropathy & cardiac complications.
Besides these, this combination may be used in the deficiency of these vitamins.
Pharmacology
This is a combined preparation of Vitamin B1 (Thiamine Mononitrate), Vitamin B6 (Pyridoxine Hydrochloride) and Vitamin B12 (Cyanocobalamin). These vitamins play an essential role as co-enzyme in the metabolism of nervous system. supports the regeneration of nerve fibers and myelin sheath by activation of the nerve cell metabolism and the natural repair mechanism.
Dosage
Tablets: 1 to 3 tablets per day or as directed by the physician. Injection: Ampules are preferably injected intramuscularly (deep intragluteal). In severe cases 1 ampoule daily until the acute symptoms subside. For milder cases and follow up therapy 2 to 3 ampoules per week.
Interaction
Vitamin B6 (Pyridoxine Hydrochloride) reduces therapeutic effect of Levodopa but it does not occur if a dopa decarboxylase inhibitor is also given. Neomycin, Chloramphenicol, Aminosalisylic acid & H2 receptor antagonist may reduce Vitamin B12 absorption.
Contradiction
It should not be used in patients with known hypersensitivity to Thiamine, Cobalt or any other component of these preparations.
Side Effect
Very rarely hypersensitive reaction and sensitivity disturbance may occur.
Pregnancy
No risks have become known associated with the use of this combination during pregnancy at the recommended dosage. Vitamin B1, B6 & B12 are secreted into the breast milk but risks of overdose for the infant are not known.
Precaution
It should be avoided in case of hypersensitivity to Thiamine, Cobalt or any other component of these preparations. Cyanocobalamin should not be given before a diagnosis has been fully established because of the masking symptoms of subacute degeneration of the spinal cord.
Overdose
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.